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Generation and repair of AID-initiated DNA lesions in B lymphocytes

Zhangguo Chen,Jing H. Wang

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 201-216 doi: 10.1007/s11684-014-0324-4

Abstract: In mammalian B cells, this process includes somatic hypermutation (SHM) and class switch recombinationreview, we focus on the molecular mechanisms that regulate the specificity of AID targeting and the repair

Keywords： class switch recombination     somatic hypermutation     activation-induced deaminase     DNA repair     genomic instability    

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Expression and function of DMT1 without IRE in C6 cells mediated by recombinant adenovirus

Xixun DU*, Huamin XU*, Hong JIANG, Jun WANG, Lei WANG, Junxia XIE

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 67-71 doi: 10.1007/s11684-009-0010-0

Abstract: Divalent metal transporter 1 (DMT1) is a ferrous iron import protein. The improper expression of DMT1 is involved in neurodegenerative diseases. In the present study, we constructed a recombinant adenovirus containing the gene of DMT1 without the iron response element (DMT1-IRE) and investigated its expression and function in the C6 glioma cell line. The DMT1-IRE gene, obtained by RT-PCR, was cloned into the shuttle plasmid pAdTrack-CMV containing green fluorescent protein (GFP) reporter gene. Linearized plasmid pAdTrack-CMV-DMT1-IRE was subsequently co-transformed into ( ) BJ5183 cells along with an adenoviral backbone plasmid pAdEasy-1 after digestion with I. I-digested pAdEasy1-DMT1-IRE was then transfected into E1-transformed human embryonic kidney cells (HEK293 cells) , in which recombinant adenoviruses were generated within 7 to 10 days. The results demonstrated that we obtained the DMT1-IRE gene. pAdEasy1-DMT1-IRE yielded a large fragment, plus a smaller fragment of 4.5 kb after digestion with I. PCR confirmed pAdEasy1-DMT1-IRE contained gene DMT1-IRE, indicating the successful construction of recombinant adenovirus plasmid containing DMT1-IRE. GFP fluorescence further confirmed the generation of adenovirus. AdDMT1-IRE could efficiently infect C6 glioma cells. And cell viability decreased in Ad-DMT1-IRE infected cells after iron overload compared to the control. These results suggest that the over expressed DMT1-IRE can aggravate the iron induced cell death due to its iron influx function.

Keywords： divalent metal transporter 1     recombinant adenovirus     homologous recombination     iron    

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Effects of BTA2 as the third component on the charge carrier generation and recombination behavior of

Leijing Liu, Hao Zhang, Bo Xiao, Yang Liu, Bin Xu, Chen Wang, Shanpeng Wen, Erjun Zhou, Gang Chen, Chan Im, Wenjing Tian

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 1,   Pages 127-137 doi: 10.1007/s11705-020-1936-7

Abstract: benzotriazole (BTA)-based small molecule, BTA2, as the third component on the charge carrier generation and recombinationphoto-CELIV investigation indicates that the ternary OSCs suffer higher charge trap-limited bimolecular recombination

Keywords： third component     organic solar cells     charge carrier generation     charge carrier recombination     bimolecularrecombination    

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Bile duct injury repair — earlier is not better

Vinay K. Kapoor

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 508-511 doi: 10.1007/s11684-015-0418-7

Abstract: The timing of bile duct injury repair remains controversial.A recent review conducted in France reported 39% complications and 64% failure after immediate repairin 194 patients compared with 14% complications and 8% failure after late repair in 133 patients.Most patients with bile duct injury present with bile leak and sepsis; thus, early repair is not recommended

Keywords： bile duct injury     cholecystectomy     laparoscopic cholecystectomy    

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Mobile platform for hydraulic turbine blade repair robot

GUI Zhongcheng, CHEN Qiang, SUN Zhenguo, ZHANG Wenzeng, LIU Kang

Frontiers of Mechanical Engineering 2008, Volume 3, Issue 2,   Pages 164-169 doi: 10.1007/s11465-008-0035-0

Abstract: adapt to complex spatial surfaces, which satisfy the requirements of a hydraulic turbine blade in-situ repair
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Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma

Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 730-740 doi: 10.1007/s11684-019-0687-7

Abstract: GATA binding protein 3 (GATA3) and mismatch repair (MMR) deficiency contribute to the development of

Keywords： upper tract urothelial carcinoma     GATA binding protein 3     mismatch repair     microsatellite instability     prognosis    

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Experimental study and field application of calcium sulfoaluminate cement for rapid repair of concrete

Yanhua GUAN, Ying GAO, Renjuan SUN, Moon C. WON, Zhi GE

Frontiers of Structural and Civil Engineering 2017, Volume 11, Issue 3,   Pages 338-345 doi: 10.1007/s11709-017-0411-0

Abstract: The fast-track repair of deteriorated concrete pavement requires materials that can be placed, cured,Based on the laboratory results, the CSA cement was selected as the partial-depth rapid repair materialThe data collected during and after the repair show that the CSA cement concrete had good short-termand long-term performances and, therefore, was suitable for the rapid repair of concrete pavement.

Keywords： Sulfoaluminate (CSA) cement     Type III cement     coefficient of thermal expansion (CTE)     shrinkage     rapid repair    

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Evidence for lung repair and regeneration in humans: key stem cells and therapeutic functions of fibroblast

Xuran Chu, Chengshui Chen, Chaolei Chen, Jin-San Zhang, Saverio Bellusci, Xiaokun Li

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 262-272 doi: 10.1007/s11684-019-0717-5

Abstract: Repair, on the other hand, allows restoring the function of an existing but failing organ.The recognition that human lungs can both repair and regenerate is quite novel, the concept has not beenWe present evidence that the human adult lung does repair and regenerate and introduce different waysVarious types of lung stem cells are capable of proliferating and differentiating upon injury driving the repair

Keywords： FGF     human lung     repair     regeneration     stem cells    

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Effect of natural pozzolan content on the properties of engineered cementitious composites as repair

Said CHOUCHA, Amar BENYAHIA, Mohamed GHRICI, Mohamed Said MANSOUR

Frontiers of Structural and Civil Engineering 2018, Volume 12, Issue 3,   Pages 261-269 doi: 10.1007/s11709-017-0394-x

Abstract: mechanical properties and durability characteristics on Engineered Cementitious Composites (ECC) as repairThis study focused on the evaluation of the most factors influencing compatibility between the repairThis lower Young’s modulus is desirable for repair concrete, because it prevents the stresses induced

Keywords： natural pozzolan     engineered cementitious composites     mechanical strengths     elastic modulus     capillary absorption     drying shrinkage    

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Statistical analysis of recombination properties of the boron-oxygen defect in p-type Czochralski silicon

Nitin NAMPALLI,Tsun Hang FUNG,Stuart WENHAM,Brett HALLAM,Malcolm ABBOTT

Frontiers in Energy 2017, Volume 11, Issue 1,   Pages 4-22 doi: 10.1007/s11708-016-0442-6

Abstract: to investigate two important aspects of carrier lifetime analysis: ① the methods used to extract the recombinationthe BO defect ( ) vary widely depending on the specific method used to extract the defect-specific recombination

Keywords： Czochralski silicon     boron-oxygen defect     injection dependent lifetime spectroscopy     goodness-of-fit     repeatability error    

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Evaluation and Recombination of Property Right Configuration for Urban Water Supply System

Xiao Wen,Ouyang Fangrui,Wang Xianjia

Strategic Study of CAE 2004, Volume 6, Issue 7,   Pages 48-52

Abstract:

In this paper, two basic models of recombination of property right configuration for urban water supply

Keywords： urban water supply system     property right configuration     recombination of property right     evaluation of    

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Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma

Na Qin, Yuancheng Li, Cheng Wang, Meng Zhu, Juncheng Dai, Tongtong Hong, Demetrius Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Gary Goodman, Stig E. Bojesen, Maria Teresa Landi, Mattias Johansson, Angela Risch, H-Erich Wichmann, Heike Bickeboller, Gadi Rennert, Susanne Arnold, Paul Brennan, John K. Field, Sanjay Shete, Loic Le Marchand, Olle Melander, Hans Brunnstrom, Geoffrey Liu, Rayjean J. Hung, Angeline Andrew, Lambertus A. Kiemeney, Shan Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Penella Woll, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Victoria L. Stevens, Guangfu Jin, David C. Christiani, Zhibin Hu, Christopher I. Amos, Hongxia Ma, Hongbing Shen

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 275-291 doi: 10.1007/s11684-020-0779-4

Abstract: Analysis revealed that AD genes were primarily involved in immune-related pathways, while SqCC genes were homologousrecombination deficiency related.

Keywords： lung cancer     genome-wide association study     function annotation     immune     homologous recombination repair    

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Investigating peak stresses in fitting and repair patches of buried polyethylene gas pipes

Reza KHADEMI ZAHEDI, Pouyan ALIMOURI, Hooman KHADEMI ZAHEDI, Mohammad SHISHESAZ

Frontiers of Structural and Civil Engineering 2020, Volume 14, Issue 1,   Pages 147-168 doi: 10.1007/s11709-019-0587-6

Abstract: The second objective is to study the effectiveness of polyethylene repair patches which are used to mendAdditionally, due to the application of pipe joints, and repair patches local stresses superimposed onThe pipe is assumed to be made of PE80 resin and its jointing socket, and the repair patch is PE100 material

Keywords： Ansys software     polyethylene     buried pipelines     polyethylene joints     polyethylene patches     peak von Mises stress     soil-pipe interaction     temperature variation    

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Regulation and function of histone acetyltransferase MOF

Yang Yang, Xiaofei Han, Jingyun Guan, Xiangzhi Li

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 79-83 doi: 10.1007/s11684-014-0314-6

Abstract: In this study, we discuss the important roles of MOF in DNA damage repair, apoptosis, and tumorigenesis

Keywords： MOF     histone acetyltransferase     DNA damage repair     tumorigenesis     embryonic stem cells    

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Comparing the effects of Bassini versus tension-free hernioplasty: 3 years’ follow-up

Yulong SHI, Zhongxue SU, Leping LI, Hongjun LIU, Changqing JING,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 463-468 doi: 10.1007/s11684-010-0050-5

Abstract: recurrence rate in the Bassini group was 8.9% (24/269), significantly higher than that in the tension-free repairThe average hospital stay in the Bassini group was longer than that in the tension-free repair group

Keywords： hernioplasty     Bassini repair     tension-free repair     complication    

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Title Author Date Type Operation

Generation and repair of AID-initiated DNA lesions in B lymphocytes

Zhangguo Chen,Jing H. Wang

Journal Article

Expression and function of DMT1 without IRE in C6 cells mediated by recombinant adenovirus

Xixun DU*, Huamin XU*, Hong JIANG, Jun WANG, Lei WANG, Junxia XIE

Journal Article

Effects of BTA2 as the third component on the charge carrier generation and recombination behavior of

Leijing Liu, Hao Zhang, Bo Xiao, Yang Liu, Bin Xu, Chen Wang, Shanpeng Wen, Erjun Zhou, Gang Chen, Chan Im, Wenjing Tian

Journal Article

Bile duct injury repair — earlier is not better

Vinay K. Kapoor

Journal Article

Mobile platform for hydraulic turbine blade repair robot

GUI Zhongcheng, CHEN Qiang, SUN Zhenguo, ZHANG Wenzeng, LIU Kang

Journal Article

Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma

Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He

Journal Article

Experimental study and field application of calcium sulfoaluminate cement for rapid repair of concrete

Yanhua GUAN, Ying GAO, Renjuan SUN, Moon C. WON, Zhi GE

Journal Article

Evidence for lung repair and regeneration in humans: key stem cells and therapeutic functions of fibroblast

Xuran Chu, Chengshui Chen, Chaolei Chen, Jin-San Zhang, Saverio Bellusci, Xiaokun Li

Journal Article

Effect of natural pozzolan content on the properties of engineered cementitious composites as repair

Said CHOUCHA, Amar BENYAHIA, Mohamed GHRICI, Mohamed Said MANSOUR

Journal Article

Statistical analysis of recombination properties of the boron-oxygen defect in p-type Czochralski silicon

Nitin NAMPALLI,Tsun Hang FUNG,Stuart WENHAM,Brett HALLAM,Malcolm ABBOTT

Journal Article

Evaluation and Recombination of Property Right Configuration for Urban Water Supply System

Xiao Wen,Ouyang Fangrui,Wang Xianjia

Journal Article

Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma

Na Qin, Yuancheng Li, Cheng Wang, Meng Zhu, Juncheng Dai, Tongtong Hong, Demetrius Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Gary Goodman, Stig E. Bojesen, Maria Teresa Landi, Mattias Johansson, Angela Risch, H-Erich Wichmann, Heike Bickeboller, Gadi Rennert, Susanne Arnold, Paul Brennan, John K. Field, Sanjay Shete, Loic Le Marchand, Olle Melander, Hans Brunnstrom, Geoffrey Liu, Rayjean J. Hung, Angeline Andrew, Lambertus A. Kiemeney, Shan Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Penella Woll, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Victoria L. Stevens, Guangfu Jin, David C. Christiani, Zhibin Hu, Christopher I. Amos, Hongxia Ma, Hongbing Shen

Journal Article

Investigating peak stresses in fitting and repair patches of buried polyethylene gas pipes

Reza KHADEMI ZAHEDI, Pouyan ALIMOURI, Hooman KHADEMI ZAHEDI, Mohammad SHISHESAZ

Journal Article

Regulation and function of histone acetyltransferase MOF

Yang Yang, Xiaofei Han, Jingyun Guan, Xiangzhi Li

Journal Article

Comparing the effects of Bassini versus tension-free hernioplasty: 3 years’ follow-up

Yulong SHI, Zhongxue SU, Leping LI, Hongjun LIU, Changqing JING,

Journal Article